What is TCMSID?

TCMSID, a Traditional Chinese Medicine Simplified Integrated Database, which contains 499 herbs registered in the Chinese pharmacopoeia with 20015 ingredients including comprehensive annotations, was developed to achieve TCM Simplification. In this database, several key ingredients can be screened as representatives of the whole TCM to capture potential targets via implementing multi-tool target prediction. Therefore, Networks among TCM herbs, formulations, ingredients, potential targets can be constructed to facilitate clarifying function and mechanisms of the TCM.

Highlights:

  • Constructed a Traditional Chinese Medicine Simplified Integrated Database containing 20015 herbal ingredients;
  • Evaluated key herbal ingredients that exert pharmacological effects;
  • Evaluated the main active ingredients in traditional Chinese medicine;
  • Evaluated 14 kinds of ADME/T properties for all ingredients;
  • Evaluated the structural reliability of all ingredients
  • Provided specific structure category of each ingredient;
  • Evaluated 8 commonly used physicochemical properties;
  • Provided potential targets of ingredients by multi target prediction tools;
  • Constructed the networks between herbs and potential targets;

Statistics

Total Herbs
499
3 Added 2019.07.01
Total Ingredients
20,015
34 Added 2019.07.03
Herb-Ingredient Pairs
50,053
200 Last updates
Total Targets
3,270
20 Added 2019.07.03

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News & Updates

  • Version 1.1.0(2020-5-5). Added the whole standard formulation simplify pipeline.
  • Version 1.0.10(2018-9-8). ADMET and target prediction functions were added in the tools page.
  • Version 1.0.9(2019-9-5). chemical similarity search function was added in the tools page
  • Version 1.0.8(2019-9-01). known drugs including FDA approved drugs with comprehensive information were added.
  • Version 1.0.7(2019-8-21).The network analysis function based on Cytoscape was added in the target page.
  • Version 1.0.6(2019-8-7). detailed annotations and references as well as organism information of target proteins were added.
  • Version 1.0.5(2019-7-22). potential targets of ingredients based on muti-tool were predicted.
  • Version 1.0.4(2019-6-30). structural characteristics, reliability annotations, pharmacokinetic and physicochemical properties were calculated for ingredients.
  • Version 1.0.3(2019-6-9). significance degree annotations of ingredients were added.
  • Version 1.0.2(2019-5-23). another 674 ingredients were supplemented..
  • Version 1.0.1(2019-4-20). 449 herbs with 17246 ingredients with comprehensive information were added..
  • Version 1.0(2019-3-1). The TCMSID Version 1.0 was released.